EXPLORING THE PROGRESSION OF DRUG DEPENDENCE IN A METHAMPHETAMINE SELF-ADMINISTRATION RAT MODEL THROUGH TARGETED AND NON-TARGETED METABOLOMICS ANALYSES

Abstract Persistent neurochemical and biological disturbances resulting from repeated cycles of drug reward, withdrawal, and relapse contribute to drug dependence.Methamphetamine (MA) is a psychostimulant with substantial abuse potential and neurotoxic effects, primarily affecting monoamine neurotransmitter systems in the brain.In this study, we ai

Recent advances in atmospheric transport model inversions could significantly reduce uncertainties in land carbon uptake through the assimilation of CO2 concentration measurements at weekly and shorter timescales.The potential of these measurements for reducing biases in estimated land carbon sinks depends on the strength of covariation between sur

Shield tunnels are increasingly monitored using 3D laser scanning technology to generate high-resolution point cloud data, which serve as a critical foundation for precise deformation analysis.This study introduces an advanced methodology for analyzing tunnel cross-section displacements, leveraging point cloud data captured by the Self-Mobile Intel

Abstract Background Although several distribution patterns of periprostatic neurovascular bundles have been proposed, variant dissection technique based on these patterns still confused surgeons.The aim of this study was to describe the periprostatic neurovascular bundles and their relationship with the fascicles around prostate and provide the acc